Heigl allegedly said her decision was because she wanted to focus more on her family.
She developed a relationship with Mark Sloan before Lexie met her demise following a plane crash.
And the storylines were sort of, you know, heading in different directions.
Sandra Oh After ten seasons starring as fan favourite Cristina Yang, Sandra Oh decided it was time to move on and hung up her scrubs for a final time in 2014.
Nathan Riggs added a little romance back in Meredith Grey's life when he joined the staff at Grey Sloan Memorial during season 12.